Abstract Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance. and the expression of the Foxp3 gene is indispensable to the differentiation of regulatory T cells. IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiation. but the detailed mechanisms are still unclear. https://www.jmannino.com/limited-save-Doodle-Always-Ranchy-Stainless-Steel-Hugger-12oz-big-sale/